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Analysis Of Urinary Organic Acids - SRA Instruments

Analysis Of Urinary Organic Acids

Clinical kits

Description

Human urine is a complex biofluid of diverse small polar metabolites such as organic acids. Organic acidurias are inborn errors of metabolism given rise to by defections of inherited enzymes which lead to accumulation excess amounts of normal organic acids in human urine. For this reason qualitative and quantitative analyses of urinary organic acids are prominent diagnostic tools for the interpretation of metabolite profile that reflects inherited metabolic disorders. Conventionally gas chromatography coupled to mass sepectrometry (GC-MS) is used in spite of disadvantages as limititaton to volatile and thermally stable analytes thereby obligating of time consuming derivatization process.
At this point, “Jasem-Organic Acids” method overcomes abovementioned drawbacks by using liquid chromatography tandem mass spectrometry (LC-MS/MS). Jasem method ensures quantification of 54 organic acids by absence of derivatization simplified sample preperation to diluting. Jasem offers two panels achieving sufficient chromatographic separation for crucial isomers by LC-MS/MS.

Features
Analysis of 54 organic acids without derivatization.
Quick and easy sample preparation; just dilution!
12 minutes run for each panel (Total analysis time 24 minutes-Panel 1&2)
Successful chromatographic separation of isomers.

PANEL-1
2-Methylcitrate
2-OH-Phenylacetic acid
2-OH-Butyric acid
2-Oxoadipic acid
3-Methylglutaconic acid
3-OH-2-Methylbutanoic acid
3-OH-3-Methylglutaric acid
3-OH-Butyric acid
3-OH-Isobutyrate
3-Phenyllactic acid
4-OH-Phenylacetic acid
Fumaric acid
Glycolic acid
Hexanoylglycine
Homogentisic acid
Malic acid
Malonic acid
N-(3-Phenylpropionyl) glycine
N-Acetylaspartic acid
N-Acetyltyrosine
N-Isovalerylglycine
Oxoproline
4-OH-Phenyllactic acid
Propionylglycine
Sebacic acid

PANEL-2
2-OH-Glutaric acid
2-OH-3-Methylpentanoic  acid
2-OH-Isocaproic acid
2-OH-Isovaleric acid
3-OH-Glutaric acid
3-OH-Propanoic acid
3-Methylcrotonyl glycine
3-Methylglutaric acid
3-Methyl-2-oxovaleric  acid
3-OH-Isovaleric acid
3-OH-Pentanoic acid
4-Methyl-2-oxovaleric  acid
4-OH-Phenylpyruvic acid
Adipic acid
2-ketoglutaric acid
Citric acid
Ethylmalonic acid
Glutaconic acid
Glutaric acid
Lactic acid
Methylmalonic acid
Orotic acid
Phenylpyruvic acid
Pyruvic acid
Succinic acid

 

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