Homocysteine is a non-essential sulfur containing amino acid closely linked to the essential amino acid methionine. Homocysteine is rapidly oxidized in plasma into homocystine and cysteine-homocysteine disulfide. Total plasma homocysteine is the sum of homocysteine and its oxidized forms.
The determination of total homocysteine plays an indicator role in diagnosis and therapy of folate, vitamin B12 and vitamin B6 deficiencies. In addition, several observational studies have confirmed that increased total homocysteine is an independent predictor of cardiovascular risk.
Jasem method ensures straightforward analysis of homocysteine, in serum, plasma and dry blood spot (DBS) during 5.0 minutes.
No need on-line SPE
Use of only one standard HPLC system and one column.
Quick and easy sample preparation.
Short analysis time (Total analysis time 5 min).