dpx lc solution

gerstel

The extraction is performed much faster than with traditional SPE techniques. Wide range of applications: drugs of abuse, therapeutic drug monitoring, comprehensive screening, pharmacology studies (NNK), as well as pesticides.

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Automated Disposable Pipette Extraction DPX

Extraction in Seconds

DPX is a fast and efficient SPE technique used for a wide range of applications such as drugs of abuse, therapeutic drug monitoring, comprehensive screening, pharmacology studies (NNK), as well as pesticides in fruit and vegetables. DPX is based on unique and patented SPE devices: Pipette tips that incorporate loosely contained sorbent material, which is mixed with the sample solution. Turbulent air bubble mixing creates a suspension of sorbent in the sample ensuring optimal contact and highly effi cient extraction. The extraction is performed much faster than with traditional SPE techniques.

The Disposable Pipette Extraction DPX technique was developed by Professor William E. Brewer, Ph.D. from the University of Southern Carolina. Professor Brewer is the Owner-President of DPX Labs.The DPX technique has been automated by GERSTEL using the MultiPurpose Sampler MPS.

Automated Disposable Pipette Extraction DPX offers:

  • Fast Extraction: Equilibration and elution occur in seconds
  • Low detection limits: Less than 250 µl liquid sample like blood or urine required to reach very low detection limits when combined with large volume injection
  • Excellent reproducibility and accuracy
  • Complete automation including added sample preparation steps and GC/MS or LC/MS analysis

DPX for LC (LC/MS) and GC (GC/MS), DPX coupled to your chromatographic system

DPX methods are readily automated using the GERSTEL MPS, which can introduce the extract into a GC/MS or LC/MS system. Additional sample preparation steps can be performed, including derivatization or adding an internal standard. The analyst only needs to place the samples in the MPS autosampler and activate the sequence table from the MAESTRO software. Everything else is performed automatically including GC/MS and LC/MS analysis.

GERSTEL MAESTRO PrepAhead provides automated overlapping of sample preparation and analysis for highest throughput and system utilization.

Automated DPX solution for GC and GC/MS
For coupling DPX to a GC (GC/MS) system the DualRail variant of the MultiPurpose Sampler MPS is needed, thus enabling to use two different syringes, one for the DPX process, another one for GC (GC/MS) introduction. Lowest detection limits and highest thoughput can be obtained when using large volume injection with the GERSTEL Cooled Injection System CIS. In this case no additional concentration step is needed.

Automated DPX solution for LC and LC/MS
For coupling DPX to an LC (LC/MS) system a two tower variant of the MultiPurpose Sampler MPS is used enabling to use one syringe for the DPX process and one for LC (LC/MS) introduction.